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Journal of Health Psychology, Vol. 13, No. 4, 481-494 (2008)
DOI: 10.1177/1359105308088519
© 2008 SAGE Publications

Psychological and Behavioural Impact of Genetic Testing Smokers for Lung Cancer Risk

A Phase II Exploratory Trial

Saskia C. Sanderson

University College London, UK, s.sanderson{at}ucl.ac.uk

Steve E. Humphries

University College London, UK

Christina Hubbart

University College London, UK

Eluned Hughes

Institute for Child Health, London, UK

Martin J. Jarvis

University College London, UK

Jane Wardle

University College London, UK

The behavioural and psychological impact of genetic testing for lung cancer susceptibility was examined among smokers (N = 61) who were randomly allocated to a GSTM1 genetic testing group (with GSTM1-missing or GSTM1-present result) or no-test control group. The GSTM1-missing (higher risk) group reported greater motivation to quit smoking, and both genetic testing groups reported lower depression than the control group at one-week follow-up (p < .05 for all). Differences were not significant at two months follow-up. This study indicates the feasibility of much-needed research into the risks and benefits for individuals of emerging lifestyle-related genetic susceptibility tests.

Key Words: behaviour change • genetic testing • lung cancer • smoking cessation


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